Article
Characterization and regulation of the rat and human ghrelin promoters.
Endocrinology - 1 Mar 2005
Wei Wei, Wang Guiyun, Qi Xiang, Englander Ella W, Greeley George H
Abstract excerpt
Ghrelin is a recently discovered stomach hormone and endogenous ligand for the GH secretagogue receptor. The aim of these studies is to elucidate molecular mechanisms underlying regulation of the ghrelin gene. Distal and proximal transcription initiation sites are present. A short transcript, a product of the proximal site, showed a more widespread distribution. Two sets of 5'-upstream segments of the rat and...
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