Article
Generation and characterization of endonuclease G null mice.
Molecular and cellular biology - 1 Jan 2005
Irvine Ryan A, Adachi Noritaka, Shibata Darryl K, Cassell Geoffrey D, Yu Kefei, Karanjawala Zarir E, Hsieh Chih-Lin, Lieber Michael R
Abstract excerpt
Endonuclease G (endo G) is one of the most abundant nucleases in eukaryotic cells. It is encoded in the nucleus and imported to the mitochondrial intermembrane space. This nuclease is active on single- and double-stranded DNA. We genetically disrupted the endo G gene in mice without disturbing a conserved, overlapping gene of unknown function that is oriented tail to tail with the endo G gene. In these mice, the...
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