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Effects of nucleases on cell-free extrachromosomal circular DNA

21 Apr 2022

Abstract excerpt

Cell-free extrachromosomal circular DNA (eccDNA) as a distinct topological form from linear DNA has recently gained increasing research interest, with possible clinical applications as a class of biomarkers. In this study, we aimed to explore the relationship between nucleases and eccDNA characteristics in plasma. By using knockout mouse models with deficiencies in deoxyribonuclease 1 (DNASE1) or...

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PMID: 35451374
DOI: 10.1172/jci.insight.156070

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