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Article

Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.

Molecular and cellular biology - 1 Jan 2005

Cheng Hua, Cenciarelli Carlo, Nelkin Gina, Tsan Rachel, Fan Dominic, Cheng-Mayer Cecilia, Fidler Isaiah J

Abstract excerpt

hTid-1, a human homolog of the Drosophila tumor suppressor l(2)Tid and a novel DnaJ protein, regulates the activity of nuclear factor kappaB (NF-kappaB), but its mechanism is not established. We report here that hTid-1 strongly associated with the cytoplasmic protein complex of NF-kappaB-IkappaB through direct interaction with IkappaBalpha/beta and the IKKalpha/beta subunits of the IkappaB kinase complex. These...

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Identifiers

PMID: 15601829
DOI: 10.1128/MCB.25.1.44-59.2005
PMCID: PMC538758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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