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Article

hTid-1, a Human DnaJ Protein, Modulates the Interferon Signaling Pathway

1 Dec 2001

Abstract excerpt

The Jak family of protein-tyrosine kinases are crucial for the signaling of a large number of different polypeptide ligands, including the interferons, many cytokines, erythropoietin, and growth factors. Through their interaction with receptors, the Jaks initiate a signaling cascade resulting in the activation of gene transcription and ultimately a cellular response to various ligands. In addition to their role...

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PMID: 11679576
DOI: 10.1074/jbc.m103683200

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