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Article

Interaction of short-range repressors with Drosophila CtBP in the embryo.

Science (New York, N.Y.) - 3 Apr 1998

Nibu Y, Zhang H, Levine M

Abstract excerpt

Human CtBP attenuates transcriptional activation and tumorigenesis mediated by the adenovirus E1A protein. The E1A sequence motif that interacts with CtBP, Pro-X-Asp-Leu-Ser-X-Lys (P-DLS-K), is present in the repression domains of two unrelated short-range repressors in Drosophila, Knirps and Snail, and is essential for the interaction of these proteins with Drosophila CtBP (dCtBP). A P-element-induced mutation...

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Identifiers

PMID: 9525852
DOI: 10.1126/science.280.5360.101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Interaction of short-range repressors with Drosophila CtBP in the embryo.PMID 9525852Read ↗

Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription.Semantic proximity Read ↗

PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions.Semantic proximity Read ↗

CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner.Semantic proximity Read ↗

Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.Semantic proximity Read ↗

Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.Semantic proximity Read ↗

Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene.Semantic proximity Read ↗

Role of CtBP in transcriptional repression by the Drosophila giant protein.Semantic proximity Read ↗

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.Semantic proximity Read ↗

KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription.Semantic proximity Read ↗

Changes in C-terminal binding protein 2 (CtBP2) corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2.Semantic proximity Read ↗

A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.Semantic proximity Read ↗

C-terminal binding proteins (CtBPs) attenuate KLF4-mediated transcriptional activation.Semantic proximity Read ↗

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