Article
Identification of a hTid-1 mutation which sensitizes gliomas to apoptosis.
FEBS letters - 17 Dec 2004
Trentin G A, He Y, Wu D C, Tang D, Rozakis-Adcock M
Abstract excerpt
Human Tid-1 (hTid-1) is a DnaJ chaperone protein with homology to the Drosophila tumor suppressor Tid56. We report the first case of a tumor-associated mutation at the human TID1 locus, which was identified in the SF767 glioma cell line giving rise to aberrantly high levels of a hTid-1(L) mutant variant. In this study, we set out to determine whether this change in hTid-1 status influences the response of glioma...
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