Article
Influenza virus entry and infection require host cell N-linked glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2004
Chu Victor C, Whittaker Gary R
Abstract excerpt
A widely held view of influenza virus infection is that the viral receptor consists of cell surface carbohydrate sialic acid, which can be present as glycoprotein or glycolipid. Here, we examined influenza virus entry and infection in Lec1 cells, a mutant CHO cell line deficient in terminal N-linked glycosylation caused by a mutation in the N-acetylglucosaminyltransferase I (GnT1) gene. We show that influenza...
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