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Article

Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22.

American journal of human genetics - 1 Dec 1994

Wilhelmsen K C, Lynch T, Pavlou E, Higgins M, Nygaard T G

Abstract excerpt

Disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC) is defined by familial adult-onset behavioral disturbance, followed by frontal lobe dementia, parkinsonism, and amyotrophy in variable proportions. A genetic etiology of DDPAC was suspected because of the familial clustering in family Mo, despite their wide geographic distribution. We have mapped the DDPAC locus to a 12-cM (sex averaged) region...

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PMID: 7977375
PMCID: PMC1918447

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