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Article

ALS-parkinsonism-dementia complex of Kii and other related diseases in Japan.

Parkinsonism & related disorders - 1 Jan 2012

Kaji Ryuji, Izumi Yishin, Adachi Yoshiki, Kuzuhara Shigeki

Abstract excerpt

The ALS/parkinsonism-dementia complex (PDC) of Kii is an endemic disease with a diverse phenotypic expression characteristic of classical ALS, parkinsonism and dementia. Its clinical and neuropathological manifestations are similar to a syndrome found in Guam, sharing classical ALS pathology together with many neurofibrillary tangles in the brain. The incidence rates of ALS declined dramatically between the 1950s...

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Source

Identifiers

PMID: 22166431
DOI: 10.1016/S1353-8020(11)70059-1

Genes

PDC
OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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