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Article

Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis.

Oncogene - 3 Feb 2005

Zaffaroni Daniela, Spinola Monica, Galvan Antonella, Falvella F Stefania, Pazzaglia Simonetta, Saran Anna, Mancuso Maria Teresa, Galbiati Federica, Pignatiello Carmen, Cabrera Wafa, Ibanez Olga, Manenti Giacomo, Dragani Tommaso A

Abstract excerpt

Analysis of seven candidate genes mapping in the 1-Mb region of the mouse pulmonary adenoma resistance 4 (Par4) locus revealed a single amino-acid change, consisting in a nonconservative Arg968Cys variation in the juxtamembrane domain of the Met proto-oncogene-encoded protein. The BALB/c strain (resistant allele) carried the Arg allele, whereas the SWR/J mouse strain (Par4-susceptible allele) carried the Cys...

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PMID: 15592501
DOI: 10.1038/sj.onc.1208324

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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