Article
Cost effectiveness of a new strategy to identify HNPCC patients.
Gut - 1 Jan 2005
Kievit W, de Bruin J H F M, Adang E M M, Severens J L, Kleibeuker J H, Sijmons R H, Ruers T J, Nagengast F M, Vasen H F A, van Krieken J H J M, Ligtenberg M J L, Hoogerbrugge N
Abstract excerpt
BACKGROUND: Distinguishing hereditary non-polyposis colorectal cancer (HNPCC) from non-hereditary colorectal cancer (CRC) can increase the life expectancy of HNPCC patients and their close relatives. AIM: To determine the effectiveness, efficiency, and feasibility of a new strategy for the detection of HNPCC, using simple criteria for microsatellite instability (MSI) analysis of newly detected tumours that can be...
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