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Article

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.

The Journal of biological chemistry - 11 Feb 2005

Hu Jianxin, McLarnon Stuart J, Mora Stefano, Jiang Jiankang, Thomas Craig, Jacobson Kenneth A, Spiegel Allen M

Abstract excerpt

Of 12 naturally occurring, activating mutations in the seven-transmembrane (7TM) domain of the human Ca2+ receptor (CaR) identified previously in subjects with autosomal dominant hypocalcemia (ADH), five appear at the junction of TM helices 6 and 7 between residue Ile819 and Glu837. After identifying a sixth activating mutation in this region, V836L, in an ADH patient, we studied the remaining residues in this...

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PMID: 15591042
DOI: 10.1074/jbc.M413403200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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