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Ras-Association Domain Family 1 Protein, RASSF1C, Is an IGFBP-5 Binding Partner and a Potential Regulator of Osteoblast Cell Proliferation

1 Aug 2005

Abstract excerpt

UNLABELLED: The goal of this study was to identify downstream signaling molecules involved in mediating the IGF-independent effects of IGFBP-5 in osteoblasts. We identified RASSF1C, a member of the RASSF1 gene products, as a IGFBP-5 binding partner and as a potential mediator of IGFBP-5 effects on ERK phosphorylation and cell proliferation. INTRODUCTION: It has been predicted that the intrinsic growth factor...

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PMID: 16007340
DOI: 10.1359/jbmr.050311

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