Article
CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasia.
International journal of oncology - 1 Jan 2005
Tsuchiya Norihiko, Wang Lizhong, Horikawa Yohei, Inoue Takamitsu, Kakinuma Hideaki, Matsuura Shinobu, Sato Kazunari, Ogawa Osamu, Kato Tetsuro, Habuchi Tomonori
Abstract excerpt
Insulin-like growth factor-I (IGF-I) plays an important role in prostate growth, hyperplasia, and carcinogenesis. Circulating IGF-I levels may be modulated by a genetic cytosine-adenine (CA) repeat polymorphism in the promoter region of IGF-I. The association of the polymorphism with the risk of prostate cancer and benign prostatic hyperplasia (BPH) was explored in 303 patients with prostate cancer, 219 patients...
Topics
- Alleles
- Asian People
- Dinucleotide Repeats
- Gene Frequency
- Genetic Predisposition to Disease
- Homozygote
- Humans
- Insulin-Like Growth Factor I
- Male
- Polymorphism, Genetic