Article
Prevalence of HLA-DRB1 genotype and altered Fas/Fas ligand expression in adrenocortical carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Mar 2005
Wolkersdörfer Gernot W, Marx Christian, Brown John, Schröder Sabine, Füssel Monika, Rieber E Peter, Kuhlisch Eberhard, Ehninger Gerhard, Bornstein Stefan R
Abstract excerpt
A distinctive feature of malignant adrenocortical neoplasms is decreased major histocompatibility complex (MHC) class II molecule expression. However, it is unknown whether there exists a restriction to certain MHC genotypes and whether this involves alterations of the Fas/Fas ligand system and thereby affects tissue homeostasis. Therefore, MHC class II phenotype and genotype and expression patterns of the...
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