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Article

Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas.

The Journal of clinical endocrinology and metabolism - 1 Feb 2003

Mune Tomoatsu, Morita Hiroyuki, Suzuki Takashi, Takahashi Yoshihito, Isomura Yukinori, Tanahashi Tetsuya, Daido Hisashi, Yamakita Noriyoshi, Deguchi Takashi, Sasano Hironobu, White Perrin C, Yasuda Keigo

Abstract excerpt

It is not understood why some adrenal adenomas are nonfunctional and others with similar histopathology cause preclinical or overt Cushing's syndrome. Two isozymes of 11 beta-hydroxysteroid dehydrogenase, types 1 and 2 (HSD11B1 and HSD11B2), are known to modulate glucocorticoid levels in other tissues and might influence circulating levels of active and inactive glucocorticoids if they were expressed in adrenal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12574226
DOI: 10.1210/jc.2001-011335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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