Evaluation of the SLC11A1 non-synonymous variant rs17235409 and tuberculosis susceptibility in a multi-ethnic population from southwestern China.

doi:10.1097/MD.0000000000049735

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Evaluation of the SLC11A1 non-synonymous variant rs17235409 and tuberculosis susceptibility in a multi-ethnic population from southwestern China.

Medicine - 17 Jul 2026

Chen Chao, Gu Dianju, Xie Yunmi

Abstract excerpt

Tuberculosis (TB) remains a major infectious disease burden, and inter-individual heterogeneity in progression from exposure to active disease suggests contributions from host genetic factors. SLC11A1 (formerly NRAMP1) encodes a phagosomal divalent cation transporter implicated in macrophage-mediated antimicrobial defense; the non-synonymous rs17235409 polymorphism (D543N) has been evaluated in multiple...

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PMID: 42470058
DOI: 10.1097/MD.0000000000049735
PMCID: PMC13384582

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SLC11A1

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