Article
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption.
Journal of the Society for Gynecologic Investigation - 1 Dec 2004
Toivonen Sari, Romppanen Eeva-Liisa, Hiltunen Mikko, Helisalmi Seppo, Keski-Nisula Leea, Punnonen Kari, Heinonen Seppo
Abstract excerpt
OBJECTIVE: We wanted to determine whether genetic variability in the gene encoding microsomal epoxide hydrolase (EPHX) contributes to individual differences in susceptibility to the occurrence of placental abruption. METHODS: The study involved 117 women with placental abruption and 115 healthy control pregnant women who were genotyped for two single nucleotide polymorphisms (SNPs), T-->C (Tyr113His) in exon 3...
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