Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequential tests for gene-environment interactions in matched case-control studies.

Statistics in medicine - 30 Dec 2004

Tweel Ingeborg van der, Schipper Maria

Abstract excerpt

The sample size necessary to detect a significant gene x environment interaction in an observational study can be large. For reasons of cost-effectiveness and efficient use of available biological samples we investigated the properties of sequential designs in matched case-control studies to test...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Computer Simulation
Share to Environmental Exposure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Models, Genetic

Share to Models, Statistical

Share to Research Design

Share to Sample Size

Source

Identifiers

PMID: 15580604
DOI: 10.1002/sim.2071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15580604-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequential tests for gene-environment interactions in matched case-control studies.PMID 15580604Read ↗

The case-combined-control design was efficient in detecting gene-environment interactions.Semantic proximity Read ↗

Efficient designs of gene-environment interaction studies: implications of Hardy-Weinberg equilibrium and gene-environment independence.Semantic proximity Read ↗

Efficient simulation of epistatic interactions in case-parent trios.Semantic proximity Read ↗

Design options for case-control studies of gene-environment interactions.Semantic proximity Read ↗

Stratified case sampling and the use of family controls.Semantic proximity Read ↗

Sample size requirements for matched case-control studies of gene-environment interaction.Semantic proximity Read ↗

Adaptively weighted association statistics.Semantic proximity Read ↗

Sample size requirements for association studies of gene-gene interaction.Semantic proximity Read ↗

Heuristic identification of biological architectures for simulating complex hierarchical genetic interactions.Semantic proximity Read ↗

Two-stage group sequential robust tests in family-based association studies: controlling type I error.Semantic proximity Read ↗

Estimating interaction between genetic and environmental risk factors: efficiency of sampling designs within a cohort.Semantic proximity Read ↗

Rapid simulation of P values for product methods and multiple-testing adjustment in association studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.