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Article

Sequential tests for gene-environment interactions in matched case-control studies.

Statistics in medicine - 30 Dec 2004

Tweel Ingeborg van der, Schipper Maria

Abstract excerpt

The sample size necessary to detect a significant gene x environment interaction in an observational study can be large. For reasons of cost-effectiveness and efficient use of available biological samples we investigated the properties of sequential designs in matched case-control studies to test for both non-hierarchical and hierarchical interactions. We derived the test statistics Z and V and their...

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PMID: 15580604
DOI: 10.1002/sim.2071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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