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Article

Conserved function of medaka pink-eyed dilution in melanin synthesis and its divergent transcriptional regulation in gonads among vertebrates.

Genetics - 1 Nov 2004

Fukamachi Shoji, Asakawa Shuichi, Wakamatsu Yuko, Shimizu Nobuyoshi, Mitani Hiroshi, Shima Akihiro

Abstract excerpt

Medaka is emerging as a model organism for the study of vertebrate development and genetics, and its effectiveness in forward genetics should prove equal to that of zebrafish. Here, we identify by positional cloning a gene responsible for the medaka i-3 albino mutant. i-3 larvae have weakly tyrosinase-positive cells but lack strongly positive and dendritic cells, suggesting loss of fully differentiated...

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Identifiers

PMID: 15579703
DOI: 10.1534/genetics.104.030494
PMCID: PMC1448775

Genes

OCA2

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