Article
Sox5 functions as a fate switch in medaka pigment cell development.
PLoS genetics - 1 Apr 2014
Nagao Yusuke, Suzuki Takao, Shimizu Atsushi, Kimura Tetsuaki, Seki Ryoko, Adachi Tomoko, Inoue Chikako, Omae Yoshihiro, Kamei Yasuhiro, Hara Ikuyo, Taniguchi Yoshihito, Naruse Kiyoshi, Wakamatsu Yuko, Kelsh Robert N, Hibi Masahiko, Hashimoto Hisashi
Abstract excerpt
Mechanisms generating diverse cell types from multipotent progenitors are crucial for normal development. Neural crest cells (NCCs) are multipotent stem cells that give rise to numerous cell-types, including pigment cells. Medaka has four types of NCC-derived pigment cells (xanthophores, leucophores, melanophores and iridophores), making medaka pigment cell development an excellent model for studying the...
Topics
- Animals
- Cell Differentiation
- Fish Proteins
- Gene Expression Regulation, Developmental
- Melanophores
- Neural Crest
- Oryzias
- PAX7 Transcription Factor
- Phenotype
- Pigmentation