Article
Drosophila klarsicht has distinct subcellular localization domains for nuclear envelope and microtubule localization in the eye.
Genetics - 1 Nov 2004
Fischer Janice A, Acosta Shelley, Kenny Andrew, Cater Courtney, Robinson Christina, Hook Jay
Abstract excerpt
The Drosophila klarsicht (klar) gene is required for developmentally regulated migrations of photoreceptor cell nuclei in the eye. klar encodes a large ( approximately 250 kD) protein with only one recognizable amino acid sequence motif, a KASH (Klar, Anc-1, Syne-1 homology) domain, at its C terminus. It has been proposed that Klar facilitates nuclear migration by linking the nucleus to the microtubule organizing...
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