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Article

Cell-type specific trafficking of expressed mutant COMP in a cell culture model for PSACH.

Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2004

Chen Tung-Ling L, Stevens Jeff W, Cole William G, Hecht Jacqueline T, Vertel Barbara M

Abstract excerpt

Pseudoachondroplasia (PSACH) is an autosomal dominant disease that mainly affects cartilage, resulting in skeletal dysplasias and early onset osteoarthritis. PSACH is caused by mutations in the cartilage oligomeric matrix protein (COMP) gene. PSACH chondrocytes accumulate unique COMP-containing lamellar structures in an expanded rough endoplasmic reticulum (rER). Although COMP is also present in tendon...

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Source

Identifiers

PMID: 15579310
DOI: 10.1016/j.matbio.2004.09.005

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cell-type specific trafficking of expressed mutant COMP in a cell culture model for PSACH.PMID 15579310Read ↗

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