Article
Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes.
Matrix biology : journal of the International Society for Matrix Biology - 1 Dec 1998
Hecht J T, Montufar-Solis D, Decker G, Lawler J, Daniels K, Duke P J
Abstract excerpt
Cartilage oligomeric matrix protein (COMP) is a large extracellular glycoprotein that is found in the territorial matrix surrounding chondrocytes. Two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1) are caused by mutations in the calcium binding domains...
Topics
- Achondroplasia
- Cartilage
- Cartilage Oligomeric Matrix Protein
- Cell Death
- Cell Differentiation
- Chondrocytes
- Extracellular Matrix Proteins
- Glycoproteins
- Humans
- Matrilin Proteins
- Mutation
- Osteochondrodysplasias
- Peroxidase
- Staining and Labeling