Article
Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues.
Matrix biology : journal of the International Society for Matrix Biology - 1 Aug 1998
Hecht J T, Deere M, Putnam E, Cole W, Vertel B, Chen H, Lawler J
Abstract excerpt
Cartilage oligomeric matrix protein (COMP), the fifth member of the -thrombospondin gene family, is an extracellular matrix calcium-binding protein. The importance of COMP is underscored by the finding that mutations in COMP cause the human dwarfing condition, pseudoachondroplasia (PSACH). Here,...
Topics
- Achondroplasia
- Cartilage
- Cartilage Oligomeric Matrix Protein
- Cells, Cultured
- Chondrocytes
- Extracellular Matrix Proteins
- Glycoproteins
- Humans
- Matrilin Proteins
- Mutation
- Recombinant Proteins
- Thrombospondins