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Article

A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004

Cockburn Ian A, Mackinnon Margaret J, O'Donnell Angela, Allen Stephen J, Moulds Joann M, Baisor Moses, Bockarie Moses, Reeder John C, Rowe J Alexandra

Abstract excerpt

Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as "rosettes." Despite a well documented association between rosetting and severe malaria, it is controversial whether rosett...

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Identifiers

PMID: 14694201
DOI: 10.1073/pnas.0305306101
PMCID: PMC314175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14694201-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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