Article
Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility.
Genes and immunity - 1 Dec 2002
Rowe J A, Raza A, Diallo D A, Baby M, Poudiougo B, Coulibaly D, Cockburn I A, Middleton J, Lyke K E, Plowe C V, Doumbo O K, Moulds J M
Abstract excerpt
Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined, and in Caucasian populations is linked to high (H) and low (L) expression alleles identified by a HindIII restriction fragment length polymorphism (RFLP). Erythrocyte CR1 may be an important factor in determining malaria susceptibility, as low expression of CR1 reduces the rosetting of uninfected erythrocytes with Plasmodium...
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