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Article

Hot spot for a large deletion in the 18- to 19-centisome region confers a multiple phenotype in Salmonella enterica serovar Typhimurium strain ATCC 14028.

Journal of bacteriology - 1 Dec 2004

Murray Sean R, de Felipe Karim Suwwan, Obuchowski Pamela L, Pike Jeremy, Bermudes David, Low K Brooks

Abstract excerpt

Loss of the Salmonella MsbB enzyme, which catalyzes the incorporation of myristate destined for lipopolysaccharide in the outer membrane, results in a strong phenotype of sensitivity to salt and chelators such as EGTA and greatly diminished endotoxic activity. MsbB- salmonellae mutate extragenically to EGTA-tolerant derivatives at a frequency of 10(-4) per division. One of these derivatives arose from...

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Identifiers

PMID: 15576802
DOI: 10.1128/JB.186.24.8516-8523.2004
PMCID: PMC532402

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Source receipt: pubmed, retrieved 7 Sept 2026.

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