Article
Extragenic suppressors of growth defects in msbB Salmonella.
Journal of bacteriology - 1 Oct 2001
Murray S R, Bermudes D, de Felipe K S, Low K B
Abstract excerpt
Lipid A, a potent endotoxin which can cause septic shock, anchors lipopolysaccharide (LPS) into the outer leaflet of the outer membrane of gram-negative bacteria. MsbB acylates (KDO)(2)-(lauroyl)-lipid IV-A with myristate during lipid A biosynthesis. Reports of knockouts of the msbB gene describe effects on virulence but describe no evidence of growth defects in Escherichia coli K-12 or Salmonella. Our data...
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