Article
Treatment with buprenorphine prior to EcoHIV infection of mice prevents the development of neurocognitive impairment.
Journal of leukocyte biology - 1 Mar 2021
Jaureguiberry-Bravo Matias, Kelschenbach Jennifer, Murphy Aniella, Carvallo Loreto, Hadas Eran, Tesfa Lydia, Scott Travis M, Rivera-Mindt Monica, Cunningham Chinazo O, Arnsten Julia H, Volsky David J, Berman Joan W
Abstract excerpt
Approximately 15-40% of people living with HIV develop HIV-associated neurocognitive disorders, HAND, despite successful antiretroviral therapy. There are no therapies to treat these disorders. HIV enters the CNS early after infection, in part by transmigration of infected monocytes. Currently, there is a major opioid epidemic in the United States. Opioid use disorder in the context of HIV infection is important...
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