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Article

Potential role of mycophenolate mofetil in the management of neuroblastoma patients.

Nucleosides, nucleotides & nucleic acids - 1 Oct 2004

Messina E, Barile L, Lupi F, Giacomello A

Abstract excerpt

In human neuroblastoma cell lines (LAN5, SHEP and IMR32), mycophenolic acid (MPA) at concentrations (10(-7)-10(-6) M) readily attainable during immunosuppressive therapy with mycophenolate mofetil (Cellcept), induces guanine nucleotide depletion leading to cell cycle arrest and apoptosis through a p53 mediated pathway (up-regulation of p53, p21 and bax and down-regulation of bcl-2 and survivin). MPA-induced...

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PMID: 15571295
DOI: 10.1081/NCN-200027770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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