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Article

The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells.

PloS one - 1 Jan 2009

Guidicelli Gwendaline, Chaigne-Delalande Benjamin, Dilhuydy Marie-Sarah, Pinson Benoît, Mahfouf Walid, Pasquet Jean-Max, Mahon François-Xavier, Pourquier Philippe, Moreau Jean-François, Legembre Patrick

Abstract excerpt

BACKGROUND: The amount of inosine monophosphate dehydrogenase (IMPDH), a pivotal enzyme for the biosynthesis of the guanosine tri-phosphate (GTP), is frequently increased in tumor cells. The anti-viral agent ribavirin and the immunosuppressant mycophenolic acid (MPA) are potent inhibitors of IMPDH. We recently showed that IMPDH inhibition led to a necrotic signal requiring the activation of Cdc42....

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Identifiers

PMID: 19430526
DOI: 10.1371/journal.pone.0005493
PMCID: PMC2675064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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