Article
Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes.
Diabetes care - 1 Aug 2003
Wang Ying, Ng Maggie C Y, Lee Shao-Chin, So Wing-Yee, Tong Peter C Y, Cockram Clive S, Critchley Julian A J H, Chan Juliana C N
Abstract excerpt
OBJECTIVE: We investigated the phenotypic features of diabetic microvascular complications and their association with a (CA)(n) microsatellite and a C/T polymorphism at the 5' region of the aldose reductase gene (ALR2) in a consecutive cohort of 738 Chinese type 2 diabetic patients. RESEARCH DESIGN AND METHODS: Of the entire patient cohort, 392 were free of diabetes complications, or uncomplicated, 159 had...
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