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Article

Functional variability of cagA gene in Japanese isolates of Helicobacter pylori.

Gene - 8 Dec 2004

Hirata Yoshihiro, Yanai Ayako, Shibata Wataru, Mitsuno Yuzo, Maeda Shin, Ogura Keiji, Yoshida Haruhiko, Kawabe Takao, Omata Masao

Abstract excerpt

CagA protein of Helicobacter pylori is injected into the epithelium, where CagA undergoes tyrosine phosphorylation and activates proliferation signals. However, the importance of these CagA activities for pathogenesis has yet to be resolved. The aim of this study is to analyze the genetic and functional variability of cagA gene of clinical strains in relation to gastric diseases. Thirty-six H. pylori strains were...

Topics

Amino Acid Sequence
Antigens, Bacterial
Bacterial Proteins
Base Sequence
Cell Line
Consensus Sequence
Genetic Variation
Helicobacter Infections
Helicobacter pylori
Humans
Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phosphorylation

Sequence Alignment

Sequence Homology, Amino Acid

Source

Identifiers

PMID: 15563842
DOI: 10.1016/j.gene.2004.08.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15563842-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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