Article
Membrane-proximal region of the carboxyl terminus of the gonadotropin-releasing hormone receptor (GnRHR) confers differential signal transduction between mammalian and nonmammalian GnRHRs.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2005
Oh D Y, Oh Da Young, Song Jung Ah, Moon Jung Sun, Moon Mi Jin, Kim Jae Il, Kim Kyungjin, Kwon Hyuk Bang, Seong Jae Young
Abstract excerpt
Recently, we demonstrated that the mammalian type-I GnRH receptor (GnRHR) has a high preference for the phospholipase C/protein kinase C (PLC/PKC)-linked signaling pathway, whereas non-mammalian bullfrog (bf) GnRHRs couple to both adenylate cyclase/protein kinase A (AC/PKA)- and PLC/PKC-linked signaling pathways. In the pre-sent study, using AC/PKA-specific reporter (cAMP-responsive element-luciferase) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.