Article
The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane.
PloS one - 8 Jul 2010
Re Michelle, Pampillo Macarena, Savard Martin, Dubuc Céléna, McArdle Craig A, Millar Robert P, Conn P Michael, Gobeil Fernand, Bhattacharya Moshmi, Babwah Andy V
Abstract excerpt
The mammalian type I gonadotropin releasing hormone receptor (GnRH-R) is a structurally unique G protein-coupled receptor (GPCR) that lacks cytoplasmic tail sequences and displays inefficient plasma membrane expression (PME). Compared to its murine counterparts, the primate type I receptor is inefficiently folded and retained in the endoplasmic reticulum (ER) leading to a further reduction in PME. The decrease in...
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