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Article

Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients.

Diabetes - 1 Feb 2004

Sasahara Miyoshi, Nishi Masahiro, Kawashima Hiromichi, Ueda Kazuya, Sakagashira Setsuya, Furuta Hiroto, Matsumoto Eisaku, Hanabusa Tadashi, Sasaki Hideyuki, Nanjo Kishio

Abstract excerpt

Common uncoupling protein 2 (UCP2) promoter polymorphism -866G/A is reported to be associated with its expression in adipose tissue and the risk of obesity in Caucasians. On the other hand, several studies suggested that UCP2 expression in beta-cells is an important determinant of insulin secretion. In the Japanese population, morbid obesity is very rare, and insulin secretion capacity is relatively low as...

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Identifiers

PMID: 14747301
DOI: 10.2337/diabetes.53.2.482

Genes

UCP2
INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients.PMID 14747301Read ↗

Association study of the -866G/A UCP2 gene promoter polymorphism with type 2 diabetes and obesity in a Tehran population: a case control study.Semantic proximity Read ↗

A common polymorphism in the promoter of UCP2 is associated with obesity and hyperinsulenemia in northern Indians.Semantic proximity Read ↗

A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.Semantic proximity Read ↗

Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism -866 G/A in the promoter region is associated with Type 2 Diabetes Mellitus among Kashmiri population of Northern IndiaSemantic proximity Read ↗

Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism - 866 G/A in the promoter region is associated with type 2 diabetes mellitus among Kashmiri population of Northern India.Semantic proximity Read ↗

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.Semantic proximity Read ↗

The common -866G/A polymorphism of the UCP2 gene in healthy Iranians compared with world populations.Semantic proximity Read ↗

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.Semantic proximity Read ↗

The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.Semantic proximity Read ↗

Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)Semantic proximity Read ↗

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.Semantic proximity Read ↗

A common polymorphism of uncoupling protein 2 gene is associated with hypertension.Semantic proximity Read ↗

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