Article
Loss of the differentiated phenotype precedes apoptosis of ROS 17/2.8 osteoblast-like cells.
Calcified tissue international - 1 Sept 1998
Ihbe A, Baumann G, Heinzmann U, Atkinson M J
Abstract excerpt
Osteoblast cells, recruited from mesenchymal precursors, initiate the final phase of bone remodeling by secreting the protein components of the bone matrix. Upon completion of remodeling, some of these osteoblasts may further differentiate, giving rise to matrix-embedded osteocytes and bone lining cells. The fate of the remaining osteoblasts is unknown, although by analogy with other cell systems, apoptotic cell...
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