Induced fit of an epitope peptide to a monoclonal antibody probed with a novel parallel surface plasmon resonance assay.

Abstract excerpt

Class II major histocompatibility complex proteins bind peptides for presentation to T-cells as part of the immune response process. Monoclonal antibody MEM-265 recognizes the peptide-free conformation of the major histocompatibility complex class II protein HLA-DR1 through specific binding to an epitope contained between residues 50-67 of the beta-chain. In previous work using alanine scanning (1), we identified...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biosensing Techniques
• Share to Biotinylation