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Article

SHP2 binds catalase and acquires a hydrogen peroxide-resistant phosphatase activity via integrin-signaling.

FEBS letters - 19 Nov 2004

Yano Sumio, Arroyo Nelly, Yano Noriko

Abstract excerpt

Here, we examined whether catalase binds SHP2 and alters SHP2 susceptibility to H2O2. Our results indicated that serum and fibrinogen commonly evoked catalase binding to SHP2 in HeLa and A549 cells in a herbimycin-A and TNFalpha sensitive manner. Expression of active catalase nearly 15-fold over control levels in tet-off HeLa cells substantially increased the SHP2 binding, and the catalase-associated SHP2...

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Identifiers

PMID: 15556604
DOI: 10.1016/j.febslet.2004.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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