Article
Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2003
Duan Zhenfeng, Duan Yifei, Lamendola Diana E, Yusuf Rushdia Z, Naeem Rizwan, Penson Richard T, Seiden Michael V
Abstract excerpt
Previous studies directed at identifying paclitaxel resistance genes in a paclitaxel-resistant subclone of the human ovarian cancer cell line SKOV-3 identified a novel cancer testis antigen, Taxol resistance-associated gene 3 (TRAG-3). Because investigation suggested that TRAG-3, located on chromosome Xq28, does not directly participate in the paclitaxel-resistant phenotype, it was hypothesized that TRAG-3 might...
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