Article
Identification of novel drug resistance mechanisms by genomic and transcriptomic profiling of glioblastoma cells with mutation-activated EGFR.
Life sciences - 1 Nov 2021
Kadioglu Onat, Saeed Mohamed E M, Mahmoud Nuha, Azawi Shaymaa, Mrasek Kristin, Liehr Thomas, Efferth Thomas
Abstract excerpt
AIMS: Epidermal growth factor receptor (EGFR) is not only involved in carcinogenesis, but also in chemoresistance. We characterized U87.MGΔEGFR glioblastoma cells with constitutively active EGFR due to deletion at the ligand binding domain in terms of gene expression profiling and chromosomal aberrations. Wild-type U87.MG cells served as control. MATERIALS AND METHODS: RNA sequencing and network analyses...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.