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Article

DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project.

PLoS biology - 1 Dec 2004

Rakyan Vardhman K, Hildmann Thomas, Novik Karen L, Lewin Jörn, Tost Jörg, Cox Antony V, Andrews T Dan, Howe Kevin L, Otto Thomas, Olek Alexander, Fischer Judith, Gut Ivo G, Berlin Kurt, Beck Stephan

Abstract excerpt

The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes and the aetiology of many diseases. Differentially methylated cytosines give rise to distinct profiles, thought to be specific for gene activity, tissue type, and...

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Identifiers

PMID: 15550986
DOI: 10.1371/journal.pbio.0020405
PMCID: PMC529316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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