Article
Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locus.
Human genetics - 1 Jan 2005
Rökman Annika, Baffoe-Bonnie Agnes B, Gillanders Elizabeth, Fredriksson Henna, Autio Ville, Ikonen Tarja, Gibbs Kenneth D, Jones Marypat, Gildea Derek, Freas-Lutz Diane, Markey Carol, Matikainen Mika P, Koivisto Pasi A, Tammela Teuvo L J, Kallioniemi Olli P, Trent Jeffrey, Bailey-Wilson Joan E, Schleutker Johanna
Abstract excerpt
In a recent genome-wide linkage (GWL) analysis of Finnish families at high risk for prostate cancer, we found two novel putative susceptibility loci at 3p25-p26 and 11q14. Here, we report the fine-mapping of these two critical regions at high resolution with 39 microsatellite markers in 16 famili...
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