Article
Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locus.
Human genetics - 1 Jan 2005
Rökman Annika, Baffoe-Bonnie Agnes B, Gillanders Elizabeth, Fredriksson Henna, Autio Ville, Ikonen Tarja, Gibbs Kenneth D, Jones Marypat, Gildea Derek, Freas-Lutz Diane, Markey Carol, Matikainen Mika P, Koivisto Pasi A, Tammela Teuvo L J, Kallioniemi Olli P, Trent Jeffrey, Bailey-Wilson Joan E, Schleutker Johanna
Abstract excerpt
In a recent genome-wide linkage (GWL) analysis of Finnish families at high risk for prostate cancer, we found two novel putative susceptibility loci at 3p25-p26 and 11q14. Here, we report the fine-mapping of these two critical regions at high resolution with 39 microsatellite markers in 16 families, including multiplex families that were not used in the GWL scan. The maximum multipoint HLOD was 3.39 at 3p26 and...
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