Article
Effects of the ligand sequence modifications on the retargeted transduction by the retroviral vector having a ligand-chimeric Env protein.
The Journal of general virology - 1 Dec 2008
Miyakawa Kei, Fujita Rika, Katane Masumi, Kubo Yoshinao, Amanuma Hiroshi
Abstract excerpt
There have been various attempts to redirect the cell entry receptor tropism of the murine leukemia virus vectors. We have recently reported the successful retargeting of the ecotropic Moloney murine leukemia virus vector. This vector (S3-D84K) contains a viral envelope (Env) protein into which a full-length (68 aa) stromal cell-derived factor-1alpha (SDF-1alpha) was inserted at Pro-79. The S3-D84K vector...
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