Article
Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas.
Pathology, research and practice - 1 Jan 2007
Do Ingu, Araujo Eduard Santini, Kalil Ricardo K, Bacchini Patrizia, Bertoni Franco, Unni K Krishnan, Park Yong-Koo
Abstract excerpt
Ewing sarcoma is a highly malignant tumor of bone preferentially arising in children and young adults. Its 5-year survival rate is only 50% despite the use of multimodal therapeutic approaches, requiring a search for new therapeutic targets and the development of novel therapeutic modalities. KIT and PDGFRs are type III receptor tyrosine kinases, and activating mutations in c-kit (which encodes KIT) and PDGFRs...
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