Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders.

doi:10.1196/annals.1316.058

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Article

Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders.

Annals of the New York Academy of Sciences - 1 Oct 2004

Higuchi Susumu, Matsushita Sachio, Masaki Toshihiro, Yokoyama Akira, Kimura Mitsuru, Suzuki Go, Mochizuki Hitoshi

Abstract excerpt

Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase-2 (ALDH2) play central roles in the metabolism of ethanol and its metabolite, acetaldehyde, in the liver. In ADH2, one nucleotide replacement causes either a super-active beta 2 subunit encoded by the ADH2*2 allele or a less active beta 1 subunit (ADH2*1 allele). In the same way, a G/A replacement at codon 487 of the ALDH2 gene produces an inactive form of...

Topics

Alcohol Dehydrogenase
Alcohol-Related Disorders
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial
Ethanol
Gene Frequency
Genetic Variation
Humans
Phenotype

Source

Open in PubMed

Identifiers

PMID: 15542751
DOI: 10.1196/annals.1316.058

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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