Article
The effect of avian influenza virus NS1 allele on virus replication and innate gene expression in avian cells.
Molecular immunology - 1 Dec 2013
Adams Sean, Xing Zheng, Li Jinling, Mendoza Kristelle, Perez Daniel, Reed Kent, Cardona Carol
Abstract excerpt
The NS1 gene encoded by Type A influenza virus circulates as two alleles, the A and B allele. The immunomodulatory properties of the NS1 A allele have been thoroughly examined; however, comparisons of allele function have been predominantly made in mammalian systems. Here we show that counter to the current understanding of allele function in mammals, the two alleles similarly regulate elements of the type I...
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