Article
Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2.8 osteoblast-like cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Mar 2003
Lohmann C H, Schwartz Z, Liu Y, Li Z, Simon B J, Sylvia V L, Dean D D, Bonewald L F, Donahue H J, Boyan B D
Abstract excerpt
Osteocytes, the predominant cells in bone, are postulated to be responsible for sensing mechanical and electrical stimuli, transducing signals via gap junctions. Osteocytes respond to induced shear by increasing connexin 43 (Cx43) levels, suggesting that they might be sensitive to physical stimuli like low-frequency electromagnetic fields (EMF). Immature osteoblasts exhibit decreased intercellular communication...
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